International Psychogeriatrics
Volume 15, Supplement 1 - 2003

Is Cholesterol a Culprit in Alzheimer’s Disease?
D. LARRY SPARKS,* M ARWAN N. SABBAGH,* JOHN C. S. BREITNER, †AND JOHN C. HUNSAKER III ‡

ABSTRACT. A pivotal role for cholesterol influence on production of the putative AD toxin, amyloid β (Aβ), has been amply demonstrated. More importantly, this relationship has consistently been identified in both in vivo and in vitro studies. Lowering cholesterol levels has been shown to cause a beneficial effect on levels in animal models, and epidemiological data indicate a beneficial effect on the risk of AD with prior statin use. Blinded, placebo-controlled clinical investigations assessing the benefit of statins on cognitive indices in mild to moderate AD are ongoing and one will be reported on soon. A prospective study assessing the effect of statin use on the risk of AD is under way as an observational component of a placebo-controlled primary prevention trial testing anti-inflammatory agents. Nevertheless, the foregoing suggests that routine monitoring and intervention for elevated cholesterol levels among the elderly could promote more than a healthy heart.

KEYWORDS: Statins; clinical trials; AD treatment; AD prevention